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Melatonin Doses Can Vary from What’s on the Label: Here’s How Much
Melatonin supplements are widely used to promote better sleep, especially among children and adults with disrupted sleep cycles. However, a recent study published by the Washington Post in June 2025 highlights a critical issue: the actual melatonin content in supplements can vary significantly from the doses printed on the product labels.
How Much Does Melatonin Actually Vary?
The FDA’s ongoing research revealed that some melatonin products contain more or less melatonin than advertised—sometimes by a margin exceeding 100%. This inconsistency raises safety and efficacy concerns, especially for sensitive populations such as children. For example, a supplement labeled to contain 3 mg of melatonin might actually have anywhere between 1.5 mg to over 6 mg, creating risks of unintended overdose or underdosing.
These findings underscore the urgent need for precise and validated testing methods to ensure consumers receive the dosage they expect and that products comply with regulatory standards.
Why Accurate Testing of Melatonin Supplements Is Essential
Inconsistent melatonin content not only undermines consumer trust but can also result in regulatory action against supplement manufacturers. To prevent such issues, manufacturers require reliable laboratory partners who:
- Ensure product content accuracy
- Validate label claims with precision
- Test for contaminant presence including heavy metals
- Verify product shelf-life and stability
That’s where Qalitex steps in.
Qalitex: Your Trusted ISO 17025-Accredited Testing Laboratory in Southern California
Located in Irvine, California, Qalitex is an ISO 17025 accredited microbiology and analytical chemistry laboratory that supports dietary supplement brands with meticulous testing services. Our ability to combine FDA-compliant product testing protocols along with USP AOAC validated methods ensures your melatonin and other supplements meet and exceed regulatory compliance.
Core Quality Control Services for Melatonin Testing Include:
- Analytical chemistry lab testing — quantification of melatonin content to validate label claims precisely
- Heavy metal analysis — ensuring supplements are free of harmful metals like lead, arsenic, and mercury
- Shelf-life and stability studies — verifying potency retention and safe consumption period
- Method development and validation — customized testing methods tailored for melatonin and complex supplement matrices
- Certificate of Analysis (CoA) testing — delivering trusted documentation required by retailers and regulatory bodies
Regulatory Compliance and Consumer Safety
Because melatonin is regulated as a dietary supplement—not a prescription drug—it falls under less stringent FDA oversight. However, manufacturers still must comply with Good Manufacturing Practices (GMPs) and labeling requirements.
Qalitex’s expertise in regulatory compliance lab services helps brands navigate complex guidelines, reduce risk of product recalls, and protect consumer health. Our rigorous testing provides peace of mind for both producers and consumers alike.
Conclusion: Accurate Melatonin Dosage Testing Is Non-Negotiable
Consumers rely on melatonin supplements for safe and effective sleep support. Yet, as studies show, there can be dramatic variances in actual melatonin amounts. Partnering with a highly accredited and experienced laboratory like Qalitex—a Southern California leader in ISO 17025 accredited testing—ensures your melatonin products maintain quality, safety, and compliance.
Get your melatonin products tested rigorously and start providing verified, trustworthy supplements today. Request a quote from Qalitex now to benefit from expert melatonin supplement testing.
Frequently Asked Questions About Melatonin Dosage Variation and Testing with Qalitex
1. Why do melatonin doses often differ from what’s printed on the label?
Variations occur due to inconsistent manufacturing processes, lack of standardized testing, or degradation during shelf-life. Without thorough testing, actual melatonin content might be significantly higher or lower than claimed.
2. How does Qalitex’s ISO 17025 accreditation impact melatonin supplement testing?
ISO 17025 accreditation certifies that Qalitex adheres to internationally recognized testing standards, assuring accurate, reliable, and reproducible melatonin content measurements critical for regulatory compliance and consumer safety. Learn more about our ISO 17025 accredited laboratory services.
3. What methods does Qalitex use for melatonin quantification?
Qalitex employs validated analytical chemistry methods, including high-performance liquid chromatography (HPLC), aligned with USP AOAC standards to precisely quantify melatonin levels and detect impurities.
4. Can Qalitex test for contaminants like heavy metals in melatonin supplements?
Yes. We provide comprehensive heavy metal analysis ensuring melatonin products meet safety thresholds for toxic elements such as lead, arsenic, cadmium, and mercury.
5. How can shelf-life and stability testing help improve melatonin product quality?
Qalitex’s stability studies determine how melatonin content changes under different storage conditions, informing expiration dating and safe usage recommendations.
6. Does Qalitex provide Certificate of Analysis (CoA) for melatonin supplements?
Yes, upon testing completion, we issue a thorough Certificate of Analysis that confirms potency, purity, and compliance — vital for Amazon sellers and distributors.
7. How do I start melatonin product testing with Qalitex in Southern California?
Reach out via our contact page to request a quote or consultation. We work closely with regional supplement brands, providing local expertise and rapid turnaround times.
Sources: Washington Post: Melatonin Doses Variation Study, June 2025
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